Synthesis and Biological Activity of 2- and 6-C-Substituted Purine Bases, Nucleosides and Acyclic Nucleotide Analogues (Bader Award Lecture)

Authors

  • M. Hocek Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague

Abstract

An overview of the author's recent achievements in the synthesis 2- and 6-C-substituted purines. Diverse approaches consisting mainly in heterocyclization, nucleophilic substitution and cross-coupling reactions were applied to the preparation of the title purines which were further transformed to target nucleosides and nucleotide analogues. Biological activity of the analogues is discussed.

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Published

2000-12-15

How to Cite

Hocek, M. (2000). Synthesis and Biological Activity of 2- and 6-C-Substituted Purine Bases, Nucleosides and Acyclic Nucleotide Analogues (Bader Award Lecture). Chemické Listy, 94(11). Retrieved from http://www-.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/2467

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Articles